Effects of novel prosteatogenic TM6SF2 and NCAN/SUGP1 polymorphisms on hepatic steatosis and non-invasive markers of liver injury in patients with chronic liver diseases

Previously we demonstrated that the frequent genetic variant PNPLA3 p.I148 M is associated with increased controlled attenuation parameter (CAP) and liver stiffness (LS) values in patients with chronic liver diseases (CLD). Recently single nucleotide variants in the TM6SF2 gene (rs58542926) and the NCAN/SUGP1 locus (rs10401969) have been reported as additional genetic determinants of fatty liver (Liu et al. Nat Comm 2014; DiStefano et al. Acta Diabetol 2014). Here, we investigate the associations between these variants and surrogate markers or liver injury, CAP and LS, in patients with CLD. In total, 174 patient…