CareLit Fachartikel

Preclinical model development for pilocytic astrocytoma

F Selt, J Kiss, J Gronych, DTW Jones, T Brummer, AE Kulozik, SM Pfister, T Milde, O Witt · Klinische Pädiatrie · 2015 · Heft 11

Dokument
1175968
CareLit-ID
Jahr
2015
Publikation
PDF
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Metadaten
DOI
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Bibliografische Angaben

Zeitschrift
Klinische Pädiatrie
Autor:innen
F Selt, J Kiss, J Gronych, DTW Jones, T Brummer, AE Kulozik, SM Pfister, T Milde, O Witt
Ausgabe
Heft 11 / 2015
Seiten
–
Erschienen: 2015-11-24 00:00:00
ISSN
0300-8630
DOI
10.1055/s-0035-1564679

Zusammenfassung

Pilocytic astrocytoma (PA), the most frequent pediatric brain tumor, exhibits an activation of MAPK-signaling by genetic aberration in nearly 100% of cases, with activating KIAA1549:BRAF-fusions being the most frequent alteration of this pathway (60 – 80%). Dealing with a single-pathway disease evokes hope for improvement of PA treatment by small molecule inhibitors of the MAPK-signalling pathway. However, faithful preclinical models are currently very limited. The paradoxical acceleration of tumor growth in PA patients treated with sorafenib, a multi-kinase inhibitor targeting the Raf pathway amongst others, hi…

Schlagworte

Tumor Astrocytoma Simian virus 40 Acceleration Astrocytes Klinische Pädiatrie