Phase-rectified signal averaging method to predict intermediate perinatal outcomes in infants with very preterm fetal growth restriction – a secondary analysis of TRUFFLE-trial

Background: Phase-rectified signal averaging (PRSA) – an innovative signal processing technique- is currently the best method in adult cardiology to predict survival after myocardial infarction. Our own research group firstly applied this method in fetal medicine. The new parameter “average acceleration capacity” (AAC) for surveillance of the fetal autonomic nervous system was derived and validated in prospective studies at hospital “Klinikum rechts der Isar”. AAC differentiated significantly better between growth restricted (FGR) fetuses and controls than the currently used computerized CTG parameter “short ter…