Angiogenic markers sFlt-1 and PIGF can be used to predict the course of early-onset preeclampsia

Angiogenic and antiangiogenic facors such as sFlt-1 and, respectively, PlGF play a major role in the pathogenesis of preeclampsia (PE) and can be used clinically as adjunct tests to diagnose PE in unclear cases. However, it is not known if these markers can predict the course of PE. For optimal management of patients with PE, such a test would be clinically useful, e.g. for indication of administration of antenatal glucocorticoids. The aim of this study was to investigate the correlation between the sFlt-1/PIGF-values and time to delivery (TTD), being a surrogate marker for the severity of the course of PE. Mate…