CareLit Fachartikel
The TGR5 protein amount is reduced in patients with primary sclerosing cholangitis (PSC)
L Spomer, J Höhne, J Hov, T Karlsen, D Nierhoff, D Häussinger, V Keitel · Zeitschrift für Gastroenterologie · 2015 · Heft 12
Dokument
1176045
CareLit-ID
Jahr
2015
Publikation
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Zusammenfassung
Introduction: The localization of TGR5 in cholangiocytes, the choleretic, anti-inflammatory and anti-apoptotic functions of the receptor suggest that TGR5 is important for the pathogenesis of biliary diseases. Additionally, for the biliary tract disease PSC an association with the frequent TGR5 exon 1 SNP rs11554825 is described, which appears with a lower TGR5 mRNA expression (measured in lymphoblastic cell line) (Hov et al., 2010). Currently no data about TGR5 localization and expression in PSC patients are known. The milieu in PSC livers is insufficiently characterized, but elevated bile salt and cytokine lev…
Schlagworte
Cytokines
Cytokine
Association
Cholangitis
Blood
Zeitschrift für Gastroenterologie
