CareLit Fachartikel
Bile acid-modulated transcript-expression in human macrophages validated by transcriptome analysis
M Wammers, D Graf, JG Bode, K Köhrer, R Deenen, D Häussinger, AK Schupp · Zeitschrift für Gastroenterologie · 2015 · Heft 12
Dokument
1176046
CareLit-ID
Jahr
2015
Publikation
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Metadaten
DOI
ja
zitierfähig
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Zusammenfassung
Cholestatic conditions are known to be associated with impaired innate and adaptive immunity, including monocytes, macrophages and T cells function. Recently, we demonstrated that bile acids modulate LPS-induced cytokine expression in primary human macrophages. Bile acids suppress LPS-induced inflammatory cytokine expressions. Moreover, bile acids adapt the activated macrophages to regulatory macrophages, characterized by an increased IL-10/IL-12 ratio. We hypothesize that bile acid influence the expression of genes, which generate the characteristic regulatory macrophages phenotype. Based on this result, an aff…
Schlagworte
Chemokines
Cytokine
Lead
Antigen-Presenting Cells
Adaptive Immunity
Dendritic Cells
Chemokine
Affect
Zeitschrift für Gastroenterologie
