TGR5 knockout mice are highly susceptible to LCA induced liver damage
C Klindt, K Deutschmann, M Reich, D Herebian, E Mayatepek, D Häussinger, V Keitel · Zeitschrift für Gastroenterologie · 2015 · Heft 12
Bibliografische Angaben
Zusammenfassung
Introduction: TGR5 (Gpbar-1) is a G-Protein-coupled membrane-bound cell surface-receptor for bile acids associated not only with the regulation of bile acid homeostasis, but also with the suppression of macrophage activity (1,2). It is expressed in several different organs and cell types, e.g. nonparenchymal liver cells and monocytes/macrophages. Thereby, TGR5 can function as a mediator for bile acids in modulating different pathologies of the liver distinguished by inflammatory processes (1,2). Lithocholic acid (LCA) is a hydrophobic bile acid with toxic properties produced by intestinal bacteria. Feeding of a…
