CareLit Fachartikel
Poly I:C-stimulated human non-parenchymal liver cells are potent suppressors of hepatitis C virus replication
M Werner, K Lukowski, A Paul, G Gerken, JF Schlaak, R Broering · Zeitschrift für Gastroenterologie · 2015 · Heft 12
Dokument
1176058
CareLit-ID
Jahr
2015
Publikation
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Metadaten
DOI
ja
zitierfähig
Bibliografische Angaben
Zusammenfassung
Background & Aims: The role of non-parenchymal liver cells as part of the hepatic, innate immune system in the defense against hepatotropic viruses such as hepatitis C is not well understood. Therefore, the aim of the study was to characterize the toll-like receptor signaling and antiviral capacity in primary human non-parenchymal liver cells. Methods: Primary human Kupffer cells, liver sinusoidal endothelial cells and hepatic stellate cells were isolated from liver tissue obtained after tumor resections or liver transplantations. Cells were stimulated with toll-like receptor agonists for 6h-24h, expression of s…
Schlagworte
Hepatitis
Cytokines
Antibodies
After
Tumor
Zeitschrift für Gastroenterologie
