IL-12 rather than immune checkpoint inhibitors contribute to the functional restoration of hepatitis D virus-specific T-cells
T Schirdewahn, J Grabowski, SO Sekyere, B Bremer, A Wranke, S Lunemann, V Schlaphoff, J Kirschner, S Hardtke, MP Manns, M Cornberg, H Wedemeyer, PV Suneetha · Zeitschrift für Gastroenterologie · 2015 · Heft 12
Bibliografische Angaben
Zusammenfassung
Hepatitis D virus (HDV) infection affects 15 – 20 million individuals world-wide and causes severely progressive hepatitis. It is unknown to what extent cellular immune responses contribute to liver disease and why immune responses fail to control viral replication in persistent HDV infection. This study aimed to analyse the mechanisms behind poor immune responses in hepatitis delta. Frequencies of immune cells and specific markers were determined by cell surface stainings of PBMCs, derived from chronic HDV patients and from healthy controls (HDV n = 49; Healthy n = 18). Cell proliferative capacity was character…
