The Tie2-Agonist Vasculotide Protects Lungs from Pneumonia-induced Barrier Disruption
B Gutbier, X Jiang, C Ehrler, TJ Mitchell, N Weissmann, P Van Slyke, DJ Dumont, N Suttorp, M Witzenrath · Pneumologie · 2016 · Heft 02
Bibliografische Angaben
Zusammenfassung
Introduction: In pneumonia, pathogen-host interaction evokes inflammation and disruption of pulmonary endothelial barrier integrity resulting in acute lung injury despite antibiotic therapy. Treatment of acute lung injury is mainly supportive, since key elements of inflammation-induced barrier disruption remain undetermined. The angiopoietins (Ang) -1 and -2 and their receptor Tie2 are involved in the regulation of vascular permeability and inflammation. Tie2-activation by Angiopoietin (Ang)-1 reduced, while Tie2-blockade by Ang-2 increased inflammation and permeability in sepsis. The PEGylated (polyethylene gly…
