Immunohistochemical study on changes of mast cell populations during allergic airway inflammation in mice using HDM model

Backround: It is necessary to clarify wheather murine asthma models display key features found in human asthma. Aims and Objectives: MCs play a role in allergic asthma by releasing numerous mediators. They are located in human lungs with changes in their distribution during allergic airway inflammation. TLR-2 and TLR-3 agonists interact with MCs, resulting in altered inflammatory processes. Here we studied numeral and phenotypical changes of MCs in lung compartments in mice under allergic conditions and treatment with TLR-agonists. Methods: Using a HDM model of allergic airway inflammation BALB/c mice were expos…