CareLit Fachartikel

Protective function of ELMO1 in renal development under diabetic conditions within zebrafish and in human diabetic nephropathy

K Sharma, K Heckler, S Stoll, JL Hillebrands, K Kynast, E Herpel, S Porubsky, PP Nawroth, J Kroll · Diabetologie und Stoffwechsel · 2016 · Heft 04

Dokument
1176417
CareLit-ID
Jahr
2016
Publikation
PDF
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Metadaten
DOI
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Bibliografische Angaben

Zeitschrift
Diabetologie und Stoffwechsel
Autor:innen
K Sharma, K Heckler, S Stoll, JL Hillebrands, K Kynast, E Herpel, S Porubsky, PP Nawroth, J Kroll
Ausgabe
Heft 04 / 2016
Seiten
–
Erschienen: 2016-04-19 00:00:00
ISSN
1861-9002
DOI
10.1055/s-0036-1580769

Zusammenfassung

Background and aims: Engulfment and cell motility 1 (ELMO1) protein functions as a guanine exchange factor for Rac1 and protects endothelial cells from apoptosis. GWAS data suggests that polymorphisms in different regions of human ELMO1 acts as a contributing factor for the development of diabetic nephropathy (DN). Thus, this study aimed to identify the role played by ELMO1 in renal development in zebrafish, under diabetic conditions, and DN patients. Materials and methods: ELMO1 expression in Wt1B:GFP zebrafish (GFP positive renal system) was knocked out using the CRISPR/Cas9 technology. Zebrafish were rendered…

Schlagworte

Apoptosis Lead Diabetologie und Stoffwechsel