GPR120 mediates nutritional effects on adipose tissue macrophage activity

Introduction: Obesity is associated with adipose tissue inflammation. Wnt5a has recently been described as a novel cytokine in metabolic inflammation. The aim of the present study was to examine, if stimulation of the Ω-3-fatty acid receptor GPR120 might be able to inhibit wnt5a release from activated adipose tissue macrophages, which might indicate a novel therapeutic target for future diabetes therapy. Materials and methods: Human THP1 macrophages were stimulated with several fatty acids and with two different pharmacological GPR120 compounds and wnt5a expression was measured by western blotting. siRNA mediate…