Interleukin-3 amplifies acute inflammation in sepsis
GF Weber, BG Chousterman, S He, AM Fenn, M Nairz, A Anzai, T Brenner, F Uhle, Y Iwamoto, CS Robbins, L Noiret, SL Maier, T Zönnchen, NN Rahbari, S Schölch, A Klotzsche-von Ameln, T Chavakis, J Weitz, S Hofer, MA Weigand, M Nahrendorf, R Weissleder, FK Swirski · Zeitschrift für Gastroenterologie · 2016 · Heft 05
Bibliografische Angaben
Zusammenfassung
Purpose: Sepsis is a frequently fatal condition characterized by an uncontrolled host reaction to microbial infection claiming millions of lives world wide every year. In the initial, inflammatory phase, the immune system overproduces cytokine-secreting leukocytes that can cause organ damage and death. Recent clinical trials targeting inflammatory mediators have failed, reflecting an urgent need for a better fundamental understanding of sepsis' pathophysiology. Methods: In a translational approach we subjected IL-3-/- and wild type (wt) mice to Cecal Ligation and Puncture (CLP), a mouse model of experimental sep…
