Aberrant transcriptional pathways in t(12;21) Acute Lymphoblastic Leukemia
A Sundaresh, L Gasparoli, M Mangolini, D Edwards, M Hubank, T Brooks, J Bartram, N Goulden, P Ancliff, J de Boer, O Williams · Klinische Pädiatrie · 2016 · Heft 05
Bibliografische Angaben
Zusammenfassung
Introduction: The single most frequent chromosomal translocation associated with childhood Acute Lymphoblastic Leukemia is the t(12;21) rearrangement that creates a fusion gene between TEL (ETV6) and AML1 (RUNX1). Although TEL-AML1+ patients have very good prognoses, relapses occur in up to 20% of patients and many patients face long-term side effects of chemotherapy. Recent data from our lab has shown that TEL-AML1 has a direct role in inducing signal transducer and activator of transcription 3 (STAT3) activation in human t(12;21) leukemia. This activation has been shown to transcriptionally induce MYC and is c…
