A soluble factor mediates alpha-1 antitrypsin-induced inhibition of ATP-induced IL-1β release by monocytic cells
R Siebers, B Fink, K Richter, S Wilker, M Küllmar, S Zukunft, N Aggarwal, A Zakrzewicz, W Padberg, S Janciauskiene, V Grau · Pneumologie · 2016 · Heft 07
Bibliografische Angaben
Zusammenfassung
Introduction: Alpha-1 antitrypsin (AAT), a major antiprotease of the lung, exerts anti-inflammatory functions via poorly defined pathways. At previous DZL meetings, we provided evidence that AAT is a potent inhibitor of ATP-induced release of IL-1β from human monocytes, and that CD36, calcium-independent phospholipase A2 (iPLA2) and nicotinic acetylcholine receptor (nAChR) subunit α9 participate in this mechanism. Here we test the hypothesis that AAT induces the release of a soluble factor X from U937 cells, which then inhibits ATP-dependent inflammasome activation via nAChR. As glycerophosphocholine (GPC) is a…
