Alteration of CD83 expression and sCD83 secretion in the course of pregnancy
K Packhäuser, D Muzzio, C Weinhold, A Tüngler, O Heidecke, J Ehrhardt, D Krüger, M Zygmunt · Geburtshilfe und Frauenheilkunde · 2016 · Heft 10
Bibliografische Angaben
Zusammenfassung
Introduction: The transmembrane molecule CD83 owns immunosuppressive features: B cells overexpressing CD83 show a high Interleukin 10 release, while CD83 positive T-cells are able to suppress the proliferation of effector CD83 negative T-cells. The membrane-bound form of CD83 generates a soluble protein (sCD83) with therapeutic potential in autoimmune diseases. We aimed to investigate if those features play a role in murine pregnancy. Materials: C57Bl/6 female mice were paired to BALB/c males and sacrificed on days 7, 14 or 18 of pregnancy. Non pregnant C57Bl/6 females served as control. Methods: CD83 expression…
