Early onset gestational diabetes (GD) as the cause for recurrent spontaneous miscarriages (RSA): RSA, pregestational metformin treatment and pregnancy outcome

Study question: Gestational diabetes is associated with RSA. A non diagnosed GD is a risk factor for RSA. Further it is known that infertility is associates with a high prevalence of early onset GD. Objective of the study was to obtain a prevalence of impaired glucose tolerance, insulin resistance and early onset GD in association with RSA and analyze pregnancy outcome in this Population. Materials, methods: Recruitment period 07/2011 to 12/2013. Fifty-seven women with confirmed RSA and subsequent pregnancy are included in the analysis. In all subjects a basic 75 g oral glucose tolerance test (OGTT) and insulin…