CareLit Fachartikel

Parkinson-Erkrankung und Neuroinflammation – Zelluläre Pathologie, Mechanismen und therapeutische Optionen

Lars Tönges, Judith Metzdorf, Samis Zella · Fortschritte der Neurologie · Psychiatrie · 2018 · Heft S 01 S 01 · S. S10-S20

Dokument
1191284
CareLit-ID
Jahr
2018
Publikation
PDF
nein
Metadaten
DOI
ja
zitierfähig

Bibliografische Angaben

Zeitschrift
Fortschritte der Neurologie · Psychiatrie
Autor:innen
Lars Tönges, Judith Metzdorf, Samis Zella
Ausgabe
Heft S 01 S 01 / 2018
Jahrgang 86
Seiten
S10-S20
Erschienen: 2018-09-01 00:00:00
ISSN
0720-4299
DOI
10.1055/s-0044-101608

Zusammenfassung

Abstract Refined examination techniques in neuropathology, more precise molecular characterization of biomaterials, and nuclear medicine studies of the CNS in Parkinson's disease provide ample evidence for relevant involvement of neuroinflammation in both post-mortem and intravital analyses. By evaluating ever larger and better-defined patient cohorts, it has also been shown that different neuroinflammatory cellular actors are involved. These cell types and their functions have been extensively studied in cell culture and animal models to understand the pathogenetic mechanisms of Parkinson's disease and form a b…

Schlagworte

Parkinson-Erkrankung M. Parkinson Neurodegeneration Neuroinflammation Gliazellen Mikroglia Parkinson’s disease glial cells microglia Astrocytes Fortschritte der Neurologie · Psychiatrie