Re-fusion of Small Mononucleated Hodgkin Cells Leads to Multinucleated Reed-Sternberg Cells
B Rengstl, S Newrzela, T Heinrich, C Weiser, FB Thalheimer, F Schmid, K Warner, S Hartmann, T Schroeder, R Küppers, MA Rieger, ML Hansmann · Klinische Pädiatrie · 2014 · Heft 03
Bibliografische Angaben
Zusammenfassung
The multinucleated Reed-Sternberg (RS) cells are pathognomonic for classical Hodgkin lymphoma (HL) and their presence is essential for diagnosis. However, the development of these giant tumor cells is controversially discussed. It was postulated that RS cells arise from mononucleated Hodgkin cells via endomitosis. Conversely, continuous single cell tracking of HL cell lines by long-term time-lapse microscopy showed that cell fusion is the main route of RS cell formation. In contrast to growth-induced formation of giant Hodgkin cells, fusion of small mononuclear cells followed by size increase gives rise to giant…
