MLL5 as Disease Contributing Gene in Classical Pediatric and Adult Hodgkin Lymphoma
A Mollweide, D Kirchberger, S Burdach, M Kremer, F Fend, M Maneck, I Blochberger, C Klein, G Richter · Klinische Pädiatrie · 2014 · Heft 03
Bibliografische Angaben
Zusammenfassung
Hodgkin lymphoma (HL) affects children as well as adults with every tenth patient being a child. The molecular pathogenesis of HL is still poorly understood and it's still unclear whether pediatric and adult HL represents the same entity. The fact that Hodgkin/Reed-Sternberg cells signify only about one percent of cells of an affected lymph node may account for the difficulty to molecularly dissect the two diseases. In order to help to clarify the molecular pathology of HL we collected single Reed-Sternberg cells by laser micro-dissection from pediatric and adult HL. After full transcriptome amplification microa…
