CareLit Fachartikel

Identification of Endogenous Retrovirus Sequences that are Associated with Hodgkin's Lymphoma Specific Gene Expression

MS Staege, K Kruse, L Kielholz, MM Ruch, N Wappler, I Volkmer, S Kewitz, I Große · Klinische Pädiatrie · 2014 · Heft 03

Dokument
1200217
CareLit-ID
Jahr
2014
Publikation
PDF
nein
Metadaten
DOI
ja
zitierfähig

Bibliografische Angaben

Zeitschrift
Klinische Pädiatrie
Autor:innen
MS Staege, K Kruse, L Kielholz, MM Ruch, N Wappler, I Volkmer, S Kewitz, I Große
Ausgabe
Heft 03 / 2014
Seiten
–
Erschienen: 2014-03-31 00:00:00
ISSN
0300-8630
DOI
10.1055/s-0034-1371100

Zusammenfassung

Question: Human endogenous retroviruses (ERV) represent approximately 10% of our DNA. The majority of these ERV loci are inactivated by mutations that disrupt open reading frames of the viral gag, pol, and env proteins. In addition, expression of most ERV elements is stringently shut off by epigenetic mechanisms. Reactivation of ERV expression has been observed in several diseases, ranging from cancer to neurodegenerative diseases. Methods: We used exon microarray analysis for the characterization of gene expression in Hodgkin's lymphoma (HL) cells in comparison to normal blood cells. We assessed a possible asso…

Schlagworte

Association Blood Cells Database Affect Blood Klinische Pädiatrie