Long Non-Coding RNAs Are Commonly Deregulated in Hodgkin Lymphoma
A van den Berg, M Tayari, G Kortman, J Sietzema, D de Jong, M Terpstra, L Visser, A Diepstra, K Kok, J Kluiver · Klinische Pädiatrie · 2014 · Heft 03
Bibliografische Angaben
Zusammenfassung
Question: Long non-coding RNAs (lncRNAs) have diverse roles at transcriptional, posttranscriptional and epigenetic mechanisms. Deregulation of lncRNA expression has been implicated in a number of cancers and for some lncRNAs a causal relationship with cancer development has been shown. We studied involvement of lncRNAs in the pathogenesis of Hodgkin lymphoma (HL). Methods: We designed a custom made microarray that contains probes for 10,509 lncRNA loci and all protein coding genes. We analyzed 6 HL cell lines and three independent samples of purified tonsillar naive, germinal center (GC) and memory B cells. Resu…
