HLA Associations in EBV Status Defined Subgroups of Classical Hodgkin Lymphoma
A Diepstra, H Xin, K Kushekhar, I Nolte, L Visser, I Bouwman, N Kouprie, R Veenstra, G van Imhoff, S Poppema, B Hepkema, A van den Berg · Klinische Pädiatrie · 2014 · Heft 03
Bibliografische Angaben
Zusammenfassung
Question: In large genome wide association studies, the human leukocyte antigen (HLA) region has been shown to be the strongest contributor to genetic susceptibility in both Epstein Barr virus (EBV) positive and negative classical Hodgkin lymphoma (cHL). In EBV+ cHL this susceptibility has been attributed to the HLA-A1 type, while HLA-A2 is protective. The aim of this study is to comprehensively type both HLA class I and class II genes in EBV+ and EBV- cHL cases. Methods: We performed a case-control genotyping study of HLA genes in 338 Dutch cHL patients using a PCR-based sequence-specific oligonucleotide probe…
