Immunological Status of the Host in Aspect of Epstein-Barr Virus Latency in Pediatric Hodgkin Lymphoma

Latent Epstein-Barr virus (EBV) infection association with Hodgkin Lymphoma (HL) is well documented. Scanty data on host immunological status in aspect of EBV latent infection of Hodgkin and Reed-Sternberg cells are available for pediatric patients. To assess the impact of latent EBV infection on immunological status of the patient analysis of 61 HL cases (2.6 – 18.0; median: 14.2 years) was performed. HIV infection and inherited immune deficiency syndromes were excluded. EBV status of neoplastic cells was determined by EBER-specific in situ hybridization and by immonohistochemical LMP-1 protein detection (respe…