Hodgkin Lymphoma Subtypes and Peripheral B-cell Lymphopenia are Associated with EBV Status in Children and Adolescents in France: A Preliminary Report of the EuroNet LH EPI Project
C Besson, S Boudjemaa, L Hamdi, R Creidy, T Leblanc, A Lambilliote, L Dainese, B Doukoure, R Krziesek, A Coulomb, J Landman-Parker · Klinische Pädiatrie · 2014 · Heft 03
Bibliografische Angaben
Zusammenfassung
Hodgkin's lymphoma (HL) microenvironment is enriched in soluble factors and direct cellular interactions known to be strong modifiers of lymphocyte homeostasis. Yet, HL tumor microenvironment differs between EBV negative and EBV positive tumors. The impact of this milieu on the peripheral lymphocytic compartments in HL patients remains to be defined. Morphological data of 153 children with HL included in EuroNet-PHL-C1 protocol were prospectively reviewed. 84 patients were also analyzed for plasmatic EBV load and peripheral lymphocytic counts. Median age was 13.5 years, ranging from 5 to 18. Male to female ratio…
