Combined Linkage and Association Studies of Antibodies against EBV Antigens Confirm the Role of HLA Class II Variants in the Control of Anti-EBNA1 IgG Levels and in the Risk of Ho…
V Pedergnana, L Syx, A Cobat, J Guergnon, P Brice, C Ferme, P Carde, O Hermine, C Le Pendeven, C Amiel, I Theodorou, L Abel, C Besson · Klinische Pädiatrie · 2014 · Heft 03
Bibliografische Angaben
Zusammenfassung
An altered anti-EBV serologic profile is associated with an increased risk of Hodgkin's lymphoma (HL) and has been shown to precede HL diagnosis. Recent studies have provided evidence for the role of genetic factors controlling both anti- viral capsid antigen (VCA) and anti- Epstein-Barr nuclear antigen-1 (EBNA-1) immunoglobulin (Ig)G levels. Here, we conducted linkage and association studies to further search for genetic factors influencing either anti-VCA or anti-EBNA-1 IgG levels in a French familial sample recruited through cases of HL. Our sample included 413 genotyped EBV-positive subjects belonging to 119…
