M2 Macrophages but not M1 Macrophages Are Associated with Worst Outcome in Classical Hodgkin Lymphoma

We have shown recently that in EBV+ paediatric classical Hodgkin lymphoma (cHL) the tumour microenvironment is characterized by a cytotoxic/Th1 profile and higher numbers of CD14+, CD68+ and CD163+ cells when compared to EBV- cases. Our results suggested also that CD163+ cells represent a heterogeneous cell population. The objectives of this study were to evaluate the macrophage polarization in the tumour microenvironment of paediatric cHL and its impact on survival. The tumour microenvironment was analysed by double-immunohistochemistry based on the combination of CD68 or CD163 with pSTAT1 (M1 macrophages), as…