CareLit Fachartikel
Genetic Variants of Interleukin 10 (IL10) are Associated with Clinical Outcome and Tumor Microenvironment Composition of Classical Hodgkin Lymphoma (cHL)
M Vera-Lozada, M Barros, A García Costa, R Hassan · Klinische Pädiatrie · 2014 · Heft 03
Dokument
1200228
CareLit-ID
Jahr
2014
Publikation
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Bibliografische Angaben
Zusammenfassung
IL10 is a immunoregulatory cytokine which expression is regulated mainly by promoter polymorphisms, which have previously been associated with prognosis in adult cHL. However, their effects on the outcome of pediatric patients remains unproven, as well as a model for the genetic control of IL10 expression, and its role in shaping the tumor microenvironment (TME). We analyzed IL10 polymorphisms in respect of therapy response, gene expression and TME composition in a group of 98 children and adolescents with cHL. Additionally, peripheral blood (PB) from 92 healthy donors were included. IL10 promoter SNPs [-1082 (r…
Schlagworte
Association
Cytokine
Tumor
Blood
Lead
Klinische Pädiatrie
