Outcomes and Patterns of Failure in Children/Adolescents with Low Risk Hodgkin Lymphoma (HL) who Are FDG-PET (PET3) Positive after AVPC Therapy

Question: The Children's Oncology Group (COG) HL studies have applied response based paradigms for titration of therapy. AHOD0431 evaluated use of complete response (CR; defined by CT and FDG-PET) at the end of 3 cycles AVPC to identify when IFRT could be obviated for low risk patients. Methods: All stage I/II patients without bulk received 3 cycles of AVPC chemotherapy. FDG-PET was captured after cycles 1 (PET1) and 3 (PET3). CR was defined as > 80% reduction in the size of nodal masses, or return to normal size on CT, and negative findings on PET3. Patients who achieved a CR received no further therapy. Those…