Comparison of Serial Plasma Galectin-1, sCD163 and sCD30 with Plasma TARC Levels as Circulating Biomarkers for Response Evaluation in Classical Hodgkin Lymphoma

Question: Plasma Thymus and Activation Regulated Chemokine (TARC), sCD30 and more recently Galectin-1 and sCD163 have been reported to be elevated in plasma or serum of untreated classical Hodgkin Lymphoma (cHL) patients. In this study we compared clinical applicability of these biomarkers in cHL response evaluation. Methods: Plasma samples were collected before and after treatment in 63 newly diagnosed cHL patients and in healthy controls. TARC, Galectin-1, sCD30 and sCD163 levels were determined by ELISA and compared to clinical characteristics and treatment response. Results: Pre-treatment plasma TARC, Galect…