Intensive Therapy Free Survival (ITFS) for Early-Stage Hodgkin Lymphoma (cHL) Including Chemotherapy and Radiation Therapy (IFRT) for Recurrence after Chemotherapy alone
F Keller, S Castellino, L Constine, S Voss, J Thomson, C Dunphy, K McCarten, L Chen, C Schwartz · Klinische Pädiatrie · 2014 · Heft 03
Bibliografische Angaben
Zusammenfassung
Introduction: AHOD0431 investigated whether a prescribed salvage regimen of conventional chemotherapy and IFRT is an effective strategy for treating children with early-stage cHL that recur after initial treatment with a minimally toxic chemotherapy regimen. Methods: AHOD0431 treated patients with IA/IIA cHL without bulk with 3 cycles of doxorubicin, vincristine, prednisone and cyclophosphamide. Patients achieving a complete response after 3 cycles received no further therapy. Those with a partial response received 21 Gy IFRT. Subjects that experienced a low-risk relapse after treatment with chemotherapy alone w…
