Treatment of Pediatric Lymphocyte Predominant Hodgkin Lymphoma (LPHL): A Report from the Children's Oncology Group

Question: LPHL typically presents with low stage disease and responds to classical HL regimens. Recurrence is uncommon, but second malignancies including non-Hodgkin lymphoma (NHL) can occur. Thus, reducing radiation exposure may be of benefit. We report the results of a prospective trial in which a selected subset of patients had surgery alone and the rest were treated with limited chemotherapy ± involved-field radiation therapy (IFRT). Methods: Patients < 21 years with newly diagnosed, low risk LPHL were eligible for AHOD03P1. Low risk was defined as clinical Stage IA or IIA without bulk disease (mediastinal m…