CareLit Fachartikel
Hodgkin's Lymphoma Specific Transcripts and Minimal Residual Disease Detection
MS Staege, I Volkmer, S Kewitz, D Körholz · Klinische Pädiatrie · 2014 · Heft 03
Dokument
1200240
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Jahr
2014
Publikation
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Zusammenfassung
Question: For leukemia, the prognostic value of minimal residual disease (MRD) measured as residual tumor cells in the bone marrow or in the blood is well established. The presence of Hodgkin's lymphoma (HL) cells in the peripheral blood of HL patients has been described. For development of methods for detection of such tumor cells, suitable markers have to be identified. Tumor-specific markers are present in all HL cell lines. E.g., clone-specific rearrangements of the immunoglobulin loci are present in HL cells and can be detected by polymerase chain reaction (PCR). In addition, HL cell lines harbor specific m…
Schlagworte
Blood
Tumor
Data Analysis
Blood Cells
After
Klinische Pädiatrie
