Classical Hodgkin Lymphoma in Guatemalan Children of Age Less than Six Show High pPrevalence of EBV, HGAL and CD137: Prognostic and Therapeutic Implications

Question: Classical Hodgkin lymphoma (CHL) in children shows a higher incidence in boys, mixed cellularity histology and EBV positivity in 27 – 54% of cases. While prognostic factors are well defined in adults, less is known about the parameters and associated underlying biological mechanisms, which drive outcomes in younger age groups. Since 2004, the Central American Association of Pediatric Hematology Oncology (AHOPCA) has treated children with CHL with uniform therapy protocols in all countries. Of the 218 children with CHL inGuatemala, 69 (32%) are less than 6 years of age. In the current study, we evaluate…