Feasibility of VECOPA a Dose-Intensive Regimen for Pediatric Intermediate and Advanced Stage Hodgkin's Lymphoma: Results of the GPOH-HD-2002/VECOPA-Pilot Study
C Mauz-Körholz, D Hasenclever, V Holzendorf, H Jürgens, S Burdach, A Eggert, F Berthold, H Müller, M Frühwald, T Klingebiel, M Metzler, D Körholz · Klinische Pädiatrie · 2014 · Heft 03
Bibliografische Angaben
Zusammenfassung
Purpose: The VECOPA (vinblastine, etoposide, cyclophosphamide, vincristine, prednisone, doxorubicine) – consolidation cycle was designed to intensify the COPDAC (cyclophosphamide, vincristine, prednisone, dacarbazine) consolidation cycle as a potential alternative procarbazine-free regimen. VECOPA was thus piloted in boys with Hodgkin's Lymphoma (HL) as a 42 days instead of a 58 days regimen. Patients & Methods: Following two induction cycles of vincristine, etoposide, prednisone and doxorubicine (OEPA) one or two VECOPA cycles were applied, followed by involved field radiotherapy with 19.8 Gy. Main endpoint was…
