Does Pathological Variability in Paediatric Nodular Lymphocyte Predominant Hodgkin Lymphoma Have Clinical Prognostic Significance?

Question: Although the pathology of typical nodular lymphocyte predominant Hodgkin lymphoma (NLPHL) is well defined, the literature describes atypical cases with diffuse, interfollicular and T cell-rich patterns, often associated with IgD expression in the LP cells. We have examined a group of paediatric NLPHL patients to determine if atypical histology correlates with treatment outcome. Methods: We reviewed the pathology of 23 cases of early stage paediatric NLPHL and assessed disease recurrence and disease progression. The cases were stained with a standard panel of antibodies and examined by an experienced ha…