Grey Zone Lymphoma in Children and Adolescents: Experience of Pediatric Hodgkin and Non-Hodgkin Study Groups

The WHO classification describes grey zone lymphomas as lymphoma between Hodgkin and Non-Hodgkin lymphoma with characteristics of both entities. The clinical relevance of this subtype is unknown for children and adolescents. A joint analysis of the German pediatric Hodgkin – and Non-Hodgkin lymphoma study groups identified 23 patients with grey zone lymphoma diagnosed between Oct. 2004 and Sept. 2013. In all but one case the diagnosis was confirmed by one of the reference pathologists of the study groups. The grey zone lymphoma was identified at the time of initial diagnosis in 15 patients, in six patients the d…