A Risk Adapted, Response- Based Therapeutic Regimen Using OEPA/COPDAC for the Treatment of Children with High Risk Hodgkin Lymphoma; from the Central American y Dominican Republic…

Purpose: Childhood Hodgkin lymphoma (HL) is highly curable in high income countries. Our previous protocol with a modified Stanford V achieved an event- and overall-survival of 50% and 60% respectively. Here we present the follow up study for high risk patients using OE*PA/COPDAC. Method: Patients received 2 cycles of OE*PA (vincristine, etoposide, prednisone, and doxorubine) and 4 cycles of COPDAC (cyclophosphamide, vincristine, prednisone, and dacarbazine) followed by involved field radiotherapy (IFRT). IFRT dose depended on the response after 2 cycles of OEPA: 20 Gys if in complete remission or 25 Gys if no c…