Cancer/Testis Antigen 96 (Dual Specificity Protein Kinase TTK) is an Interesting Target for Hodgkin's Lymphoma

Question: The prognosis of patients with a Hodgkin's lymphoma (HL) has been improved during the last years. But there are still patients which cannot be cured with current therapy regimes. Therefore it is important to identify new therapeutic targets to create new therapy options. Methods: In order to identify genes which might be associated with the resistance of HL cells against cytotoxic drugs we established a cDNA library from the relatively chemoresistant HL cell line KM-H2. We used this library for transfection of sensible cells and treated transfected cells with cisplatin. From surviving cells we re-isola…