The Evolution of Pediatric Hodgkin Lymphoma Therapy: Contemporary Protocols Significantly Reduce Radiation Exposure of Normal Tissues
R Zhou, A Ng, R Weathers, A McDonald, W Leisenring, P Goodman, M Stovall, G Armstrong, L Robison, D Hodgson · Klinische Pädiatrie · 2014 · Heft 03
Bibliografische Angaben
Zusammenfassung
Background: Survivors of childhood Hodgkin Lymphoma (HL) are at an increased risk for radiation-related toxicity. However, most estimates of the magnitude of these risks are based on historical radiotherapy (RT) treatments that encompassed large volumes of normal tissue. We evaluated the normal tissue dose associated with two recent Children's Oncology Group (COG) trials and compared them with doses reconstructed from RT plans of HL survivors in the Childhood Cancer Survivors Study (CCCS). Methods: Radiation doses to the female breast and heart were reconstructed from 50 HL survivors sampled from the CCSS cohort…
