Risk assessment of Solid Secondary Malignancies (SMN) in Childhood and Adolescent Hodgkin Lymphoma (HL) Treated with Radiotherapy (RT): Conventional RT vs. Helical Tomotherapy
G Zanella, M Mascarin, A Drigo, E Casanova Fuga, R Brunelli, MG Trovo', A Rosolen · Klinische Pädiatrie · 2014 · Heft 03
Bibliografische Angaben
Zusammenfassung
Question: This work develops risk assessments of solid SMN in survivors of childhood and adolescent HL patients (pts) using the Schneider's dose-response model for solid cancers induction (Theoretical Biology and Medical Modelling 2011), comparing conventional technique (CRT) with IMRT delivered with HT. Methods: Our cohort includes 15 pts (6 girls, 9 boys) treated with RT for HL, in age 6 – 25 years (median 17) at the RT, from 2008 to 2013. The 15 pts were representative of different RT target volumes (e.g. bilateral neck, ipsilateral neck, mediastinum, mantel-field, lombo-aortic and spleen, inverted Y, inguina…