Assessment of Gonadal Function in Young Men Treated for Hodgkin's Lymphoma during Childhood and Adolescence

Question: Is the testicular function of young men impaired after treatment of Hodgkin's lymphoma during childhood and adolescence? Methods: Testicular function was evaluated in 29 men (age: 5.0 – 18.2 years, median 14.5 years at the beginning of treatment, and 18.0 – 26.3 years, median 22.8 years at the end of observation) treated for HL between 1.01.1999 and 31.12.2008 in Department of Pediatric Oncology and Hematology PAIP JU MC in Krakow, according to HD-97 protocol. Chemotherapy (MOPP given alternatively with B-DOPA) combined with low-dose involved-field radiotherapy (15 – 25 Gy) was used in 25 men, and in 4…