Fertility Testing in Young Men After Successful Treatment of Hodgkin's Lymphoma with Procarbazine-Free Combination Regimen within the GPOH-HD 2002 Trial
J Conrad, M Stiefel, H Behre, H Jürgens, C Kramm, R Schneppenheim, A Attarbaschi, G Ebetsberger-Dachs, E Bergstraesser, D Körholz, C Mauz-Körholz · Klinische Pädiatrie · 2014 · Heft 03
Bibliografische Angaben
Zusammenfassung
Purpose: Male infertility is a frequent late effect after procarbazine-containing chemotherapy regimens for treatment of pediatric Hodgkin Lymphoma (HL). The GPOH-HD 2002 trial aimed at preservation of fertility by substituting procarbazine by dacarbazine in male patients. Two years after end of treatment fertility surrogate parameters (FSH, Inhibin B) and semen samples were analyzed. Patients and Methods: All boys received two induction cycles of OEPA (vincristine, etoposide, prednisone and doxorubicine) instead of standard OPPA (vincristine, procarbazin, prednisone and doxorubicine). Patients in intermediate (…
