Pleural Effusion in Intermediate Hodgkin Lymphoma COG Protocol AHOD0031-Evolution with Therapy and Association with Bulk Mediastinal Disease or Bone, Lung or Pleural Nodular Disea…

Purpose: Hodgkin Lymphoma (HL) can be associated with pleural effusion but its clinical significance is unclear. We performed a retrospective review of patients enrolled in the COG AHOD0031 intermediate risk HL protocol to determine the evolution of pleural effusion and to determine the significance of coexisting factors such as pleural, lung or bone mass, staging, mediastinal bulk, or response to chemotherapy. Methods: COG AHOD0031 was conducted between 2002 – 2009 to evaluate a response based treatment regimen in intermediate risk HL patients (Stages IA and IIA with bulk, IIB, IIIA and IVA) who received multi-…