Impact of Non-FDG-Avid Areas Inside a Tumour Mass in Paediatric Hodgkin Lymphoma (PHL) Patients
L Kurch, D Hasenclever, L Tchavdarova, T Georgi, D Stoevesandt, T Pelz, D Vordermark, O Sabri, C Mauz-Körholz, D Körholz, R Kluge · Klinische Pädiatrie · 2014 · Heft 03
Bibliografische Angaben
Zusammenfassung
Aim: Necrotic areas within solid tumours are known to be a source of impaired progression-free and overall survival since anaerobic conditions may lead to the formation of hypoxia resistant cells. Necrotic areas do not show FDG-uptake in PET/CT. The aim of our investigation was to characterize this phenomenon within the population of PHL patients regarding frequency, localisation, therapy intensity and outcome. Method: 1422 patients of the EuroNet-PHL-C1 trial were retrospectively reviewed for the occurrence of areas with missing tracer uptake inside the tumour lesions in FDG-PET/CT at initial staging and after…
