Definition and Significance of Osseous Involvement in Newly Diagnosed Pediatric Hodgkin Lymphoma

Purpose: The Children's Oncology Group (COG) lacks a definition for osseous involvement of HL in their protocols. In the EURO-NET PHL-C1 study osseous involvement is any biopsy proven lesion, positive bony window on CT scan, positive bone scan Tc99 only if confirmed by PET or MRI, and positive on MRI if positive in bone and adjacent soft tissue. This review aims to propose a universally acceptable definition in order to move towards harmonization of staging and response criteria in pediatric HL. Methods: We performed a comprehensive literature search through PubMed and Google scholar. Search terms included Hodgk…