Incidence and genetic characterization of childhood acute lymphoblastic leukemia with CRLF2 overexpression treated according to the AIEOP-BFM ALL 2009 protocol
J Schmäh, B Fedders, M Zimmermann, E Dagdan, P Dörge, S Bens, A Moericke, J Alten, K Bleckmann, R Siebert, M Schrappe, M Stanulla, G Cario · Klinische Pädiatrie · 2015 · Heft 07
Bibliografische Angaben
Zusammenfassung
Overexpression of the cytokine receptor-like factor 2 (CRLF2) gene in acute lymphoblastic leukemia (ALL) is caused by different aberrations like a deletion juxtaposing CRLF2 with the P2RY8 promoter, by a translocation involving the immunoglobulin heavy chain locus (IGH@), by supernumerary copies of the CRLF2 locus or by not yet identified causes. Several retrospective studies showed that only the presence of the P2RY8-CRLF2 rearrangement is associated with a high incidence of relapse in CRLF2-overexpressing precursor B-cell ALL (pB-ALL) in children; however, prospectively assessed data are missing. We therefore…
