CareLit Fachartikel

A natural combination extract of Viscum album L. containing triterpene acids and Iectins is highly effective against AML in vivo

C Delebinski, M Twardziok, S Kleinsimon, J Rolff, S Jäger, A Eggert, G Seifert · Klinische Pädiatrie · 2015 · Heft 07

Dokument
1200306
CareLit-ID
Jahr
2015
Publikation
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Metadaten
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Bibliografische Angaben

Zeitschrift
Klinische Pädiatrie
Autor:innen
C Delebinski, M Twardziok, S Kleinsimon, J Rolff, S Jäger, A Eggert, G Seifert
Ausgabe
Heft 07 / 2015
Seiten
–
Erschienen: 2015-07-27 00:00:00
ISSN
0300-8630
DOI
10.1055/s-0035-1550245

Zusammenfassung

Introduction: Aqueous Viscum album L. extracts (VAE) are widely used in complementary cancer medicine. Triterpenes also possess anti-cancer properties, but due to their low solubility they do not occur in aqueous extracts. Using cyclodextrins we solubilised mistletoe triterpenes and investigated the apoptotic effect of a whole plant extract on AML cells. Methods: The extracts contain mistletoe lectin-I (Viscum), oleanolic- acids (TT) or a combination of both (ViscumTT). Apoptosis was analyzed in U937 and HL-60. A mouse model was used to test efficacy of VAE-treatment. Results: The results revealed a caspase-8 an…

Schlagworte

Apoptosis Cyclodextrins Caspase 8 Klinische Pädiatrie