Gene expression analysis of NK cell receptors and their ligands in childhood acute lymphoblastic leukemia with involvement of the central nervous system
H Bruckmueller, J Schmäh, M Zimmermann, D Schewe, H Fedders, A Moericke, J Alten, K Bleckmann, M Schrappe, M Stanulla, G Cario · Klinische Pädiatrie · 2015 · Heft 07
Bibliografische Angaben
Zusammenfassung
Even though overt central nervous system (CNS) infiltration at the time of diagnosis in childhood acute lymphoblastic leukemia (ALL) is a rare event, CNS directed therapy is essential for all patients to reduce the risk of relapse with CNS involvement from 50% to less than 5%. Previous studies revealed a significantly higher interleukin 15 (IL15) expression in patients with an initial CNS involvement or a CNS positive relapse as compared to those without CNS disease. IL15 is known to activate NK cells and studies in mice indicated a potential role of NK cells in influencing CNS involvement by controlling systemi…
